Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice
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چکیده
منابع مشابه
Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice
The Morris Water Maze (MWM) was first established by neuroscientist Richard G. Morris in 1981 in order to test hippocampal-dependent learning, including acquisition of spatial memory and long-term spatial memory. The MWM is a relatively simple procedure typically consisting of six day trials, the main advantage being the differentiation between the spatial (hidden-platform) and non-spatial (vis...
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Mouse models have been indispensable for elucidating normal and pathological processes that influence learning and memory. A widely used method for assessing these cognitive processes in mice is the Morris water maze, a classic test for examining spatial learning and memory. However, Morris water maze studies with mice have principally been performed using adult animals, which preclude studies ...
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Mouse models of Alzheimer's Disease are essential for understanding how pathological cascades alter neural circuitry and eventually disrupt cognitive function. A key prerequisite for the use of such models, therefore, is the ability to accurately and reliably measure cognitive function. The Morris Water Maze has emerged in the field as the standard test for assessing spatial cognition. There ar...
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The Morris water maze test (MWM) is one of the most popular and established behavioral tests to evaluate rodents' spatial learning ability. The conventional training period is around 5 days, but there is no clear evidence or guidelines about the appropriate duration. In many cases, the final outcome of the MWM seems predicable from previous data and their trend. So, we assumed that if we can pr...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2011
ISSN: 1940-087X
DOI: 10.3791/2920